ABSTRACT
Objective: To utilize powder physical characteristics, optimize prescription of dry granulation process of Xiaochuan Granules (XG). Methods: Filtering of granulation prescription was guided by investigating of powder material physical characteristics such as angle repose, compression degree, water content, etc; With one time forming rate, friability and quality score of granulation process as indexes, L9(34) orthogonal test which based on the evaluation method of information entropy was used to optimize the process parameters in XG dry granulation. Results: The optimum accessory is CD, optimum dry granulation technology parameters was as follows: roll wheel pressure of 7 MPa, roll wheel speed of 10 r/min, and feed speed of 18 r/min. Conclusion: Study of physical property of preparation materials could guide filtering prescription of dry granulation preparation; The prepared granules have high forming rate with moderate hardness and good flowability, and this optimized dry granulation technology is stable and reasonable.
ABSTRACT
With the diversion rate of ginkgolide A, B, K as comprehensive evaluation indexes, the amount of activated carbon, ad- sorption time, mix rate, and adsorption temperature were selected as factors, orthogonal design which based on the evaluation method of information entropy was used to optimize activated carbon adsorption technology of ginkgo diterpene lactones meglumine injection. Opti- mized adsorption conditions were as follows: adsorbed 30 min with 0.2% activated carbon in 25 °C, 40 r ·min⁻¹, validation test re- sult display. The optimum extraction condition was stable and feasible, it will provide a basis for ginkgo diterpene lactone meglumine injection' activated carbon adsorption process.